Description
Product Characteristics:
Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). As an E2 class enzyme, UBE2W (Ubiquitin-conjugating enzyme E2 W), also known as Ubiquitin carrier protein W, is a 151 amino acid that catalyzes the conjugation of ubiquitin to proteins that are meant for lysosomal degradation. Functioning as a homodimer, UBE2W is widely expressed, with highest levels in testis. There are two isoforms of UBE2W that are produced as a result of alternative splicing events.
Subcellular location: Nucleus
Synonyms: hUBC 16, hUBC16, Probable ubiquitin conjugating enzyme E2 W, Probable ubiquitin-conjugating enzyme E2 W, UBE 2W, ube2w, UBE2W_HUMAN, Ubiquitin carrier protein W, Ubiquitin conjugating enzyme 16, Ubiquitin conjugating enzyme E2 W, Ubiquitin conjugating enzyme E2W, Ubiquitin protein ligase W, Ubiquitin-protein ligase W, FLJ11011.
Target Information: This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]